Novel phosphatidylinositol phosphate kinases with a G-protein coupled receptor signature are shared by Dictyostelium and Phytophthora.
Identifieur interne : 001F97 ( Main/Exploration ); précédent : 001F96; suivant : 001F98Novel phosphatidylinositol phosphate kinases with a G-protein coupled receptor signature are shared by Dictyostelium and Phytophthora.
Auteurs : Deenadayalan Bakthavatsalam [Allemagne] ; Harold J G. Meijer ; Angelika A. Noegel ; Francine GoversSource :
- Trends in microbiology [ 0966-842X ] ; 2006.
Descripteurs français
- KwdFr :
- Alignement de séquences (MeSH), Animaux (MeSH), Dictyostelium (enzymologie), Dictyostelium (génétique), Dictyostelium (métabolisme), Données de séquences moléculaires (MeSH), Modèles biologiques (MeSH), Phosphotransferases (Alcohol Group Acceptor) (génétique), Phosphotransferases (Alcohol Group Acceptor) (métabolisme), Phylogenèse (MeSH), Phytophthora (enzymologie), Phytophthora (génétique), Phytophthora (métabolisme), Protéines G (métabolisme), Récepteurs couplés aux protéines G (génétique), Récepteurs couplés aux protéines G (métabolisme), Séquence d'acides aminés (MeSH), Transduction du signal (MeSH).
- MESH :
- enzymologie : Dictyostelium, Phytophthora.
- génétique : Dictyostelium, Phosphotransferases (Alcohol Group Acceptor), Phytophthora, Récepteurs couplés aux protéines G.
- métabolisme : Dictyostelium, Phosphotransferases (Alcohol Group Acceptor), Phytophthora, Protéines G, Récepteurs couplés aux protéines G.
- Alignement de séquences, Animaux, Données de séquences moléculaires, Modèles biologiques, Phylogenèse, Séquence d'acides aminés, Transduction du signal.
English descriptors
- KwdEn :
- Amino Acid Sequence (MeSH), Animals (MeSH), Dictyostelium (enzymology), Dictyostelium (genetics), Dictyostelium (metabolism), GTP-Binding Proteins (metabolism), Models, Biological (MeSH), Molecular Sequence Data (MeSH), Phosphotransferases (Alcohol Group Acceptor) (genetics), Phosphotransferases (Alcohol Group Acceptor) (metabolism), Phylogeny (MeSH), Phytophthora (enzymology), Phytophthora (genetics), Phytophthora (metabolism), Receptors, G-Protein-Coupled (genetics), Receptors, G-Protein-Coupled (metabolism), Sequence Alignment (MeSH), Signal Transduction (MeSH).
- MESH :
- chemical , genetics : Phosphotransferases (Alcohol Group Acceptor), Receptors, G-Protein-Coupled.
- chemical , metabolism : GTP-Binding Proteins, Phosphotransferases (Alcohol Group Acceptor), Receptors, G-Protein-Coupled.
- enzymology : Dictyostelium, Phytophthora.
- genetics : Dictyostelium, Phytophthora.
- metabolism : Dictyostelium, Phytophthora.
- Amino Acid Sequence, Animals, Models, Biological, Molecular Sequence Data, Phylogeny, Sequence Alignment, Signal Transduction.
Abstract
G-protein coupled receptors (GPCR) and phosphatidylinositol phosphate kinases (PIPK) are important key switches in signal transduction pathways. A novel class of proteins was identified in the genomes of two unrelated organisms that harbor both a GPCR and a PIPK domain. Dictyostelium discoideum contains one GPCR-PIPK, which is crucial in cell-density sensing, and the genomes of Phytophthora sojae and Phytophthora ramorum each encode twelve GPCR-PIPKs. Intriguingly, these are currently the only species that have these two domains combined in one protein. Here, the structural and regulatory characteristics of GPCR-PIPKs are presented and discussed. It is hypothesized that, upon activation, GPCR-PIPKs are able to trigger heterotrimeric G-protein signaling and phosphoinositide second-messenger synthesis.
DOI: 10.1016/j.tim.2006.07.006
PubMed: 16876997
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Meijer</name></author><author><name sortKey="Noegel, Angelika A" sort="Noegel, Angelika A" uniqKey="Noegel A" first="Angelika A" last="Noegel">Angelika A. Noegel</name></author><author><name sortKey="Govers, Francine" sort="Govers, Francine" uniqKey="Govers F" first="Francine" last="Govers">Francine Govers</name></author></analytic><series><title level="j">Trends in microbiology</title><idno type="ISSN">0966-842X</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence (MeSH)</term><term>Animals (MeSH)</term><term>Dictyostelium (enzymology)</term><term>Dictyostelium (genetics)</term><term>Dictyostelium (metabolism)</term><term>GTP-Binding Proteins (metabolism)</term><term>Models, Biological (MeSH)</term><term>Molecular Sequence Data (MeSH)</term><term>Phosphotransferases (Alcohol Group Acceptor) (genetics)</term><term>Phosphotransferases (Alcohol Group Acceptor) (metabolism)</term><term>Phylogeny (MeSH)</term><term>Phytophthora (enzymology)</term><term>Phytophthora (genetics)</term><term>Phytophthora (metabolism)</term><term>Receptors, G-Protein-Coupled (genetics)</term><term>Receptors, G-Protein-Coupled (metabolism)</term><term>Sequence Alignment (MeSH)</term><term>Signal Transduction (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences (MeSH)</term><term>Animaux (MeSH)</term><term>Dictyostelium (enzymologie)</term><term>Dictyostelium (génétique)</term><term>Dictyostelium (métabolisme)</term><term>Données de séquences moléculaires (MeSH)</term><term>Modèles biologiques (MeSH)</term><term>Phosphotransferases (Alcohol Group Acceptor) (génétique)</term><term>Phosphotransferases (Alcohol Group Acceptor) (métabolisme)</term><term>Phylogenèse (MeSH)</term><term>Phytophthora (enzymologie)</term><term>Phytophthora (génétique)</term><term>Phytophthora (métabolisme)</term><term>Protéines G (métabolisme)</term><term>Récepteurs couplés aux protéines G (génétique)</term><term>Récepteurs couplés aux protéines G (métabolisme)</term><term>Séquence d'acides aminés (MeSH)</term><term>Transduction du signal (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Phosphotransferases (Alcohol Group Acceptor)</term><term>Receptors, G-Protein-Coupled</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>GTP-Binding Proteins</term><term>Phosphotransferases (Alcohol Group Acceptor)</term><term>Receptors, G-Protein-Coupled</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Dictyostelium</term><term>Phytophthora</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Dictyostelium</term><term>Phytophthora</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dictyostelium</term><term>Phytophthora</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Dictyostelium</term><term>Phosphotransferases (Alcohol Group Acceptor)</term><term>Phytophthora</term><term>Récepteurs couplés aux protéines G</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Dictyostelium</term><term>Phytophthora</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Dictyostelium</term><term>Phosphotransferases (Alcohol Group Acceptor)</term><term>Phytophthora</term><term>Protéines G</term><term>Récepteurs couplés aux protéines G</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Models, Biological</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Sequence Alignment</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term><term>Animaux</term><term>Données de séquences moléculaires</term><term>Modèles biologiques</term><term>Phylogenèse</term><term>Séquence d'acides aminés</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">G-protein coupled receptors (GPCR) and phosphatidylinositol phosphate kinases (PIPK) are important key switches in signal transduction pathways. A novel class of proteins was identified in the genomes of two unrelated organisms that harbor both a GPCR and a PIPK domain. Dictyostelium discoideum contains one GPCR-PIPK, which is crucial in cell-density sensing, and the genomes of Phytophthora sojae and Phytophthora ramorum each encode twelve GPCR-PIPKs. Intriguingly, these are currently the only species that have these two domains combined in one protein. Here, the structural and regulatory characteristics of GPCR-PIPKs are presented and discussed. It is hypothesized that, upon activation, GPCR-PIPKs are able to trigger heterotrimeric G-protein signaling and phosphoinositide second-messenger synthesis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16876997</PMID><DateCompleted><Year>2006</Year><Month>10</Month><Day>17</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0966-842X</ISSN><JournalIssue CitedMedium="Print"><Volume>14</Volume><Issue>9</Issue><PubDate><Year>2006</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Trends in microbiology</Title><ISOAbbreviation>Trends Microbiol</ISOAbbreviation></Journal><ArticleTitle>Novel phosphatidylinositol phosphate kinases with a G-protein coupled receptor signature are shared by Dictyostelium and Phytophthora.</ArticleTitle><Pagination><MedlinePgn>378-82</MedlinePgn></Pagination><Abstract><AbstractText>G-protein coupled receptors (GPCR) and phosphatidylinositol phosphate kinases (PIPK) are important key switches in signal transduction pathways. A novel class of proteins was identified in the genomes of two unrelated organisms that harbor both a GPCR and a PIPK domain. Dictyostelium discoideum contains one GPCR-PIPK, which is crucial in cell-density sensing, and the genomes of Phytophthora sojae and Phytophthora ramorum each encode twelve GPCR-PIPKs. Intriguingly, these are currently the only species that have these two domains combined in one protein. Here, the structural and regulatory characteristics of GPCR-PIPKs are presented and discussed. It is hypothesized that, upon activation, GPCR-PIPKs are able to trigger heterotrimeric G-protein signaling and phosphoinositide second-messenger synthesis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bakthavatsalam</LastName><ForeName>Deenadayalan</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Centre for Biochemistry, Institute of Biochemistry I, Medical Faculty and Centre for Molecular Medicine Cologne, University of Cologne, D-50931 Cologne, Germany. deen@rice.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meijer</LastName><ForeName>Harold J G</ForeName><Initials>HJ</Initials></Author><Author ValidYN="Y"><LastName>Noegel</LastName><ForeName>Angelika A</ForeName><Initials>AA</Initials></Author><Author ValidYN="Y"><LastName>Govers</LastName><ForeName>Francine</ForeName><Initials>F</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2006</Year><Month>07</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Trends Microbiol</MedlineTA><NlmUniqueID>9310916</NlmUniqueID><ISSNLinking>0966-842X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D043562">Receptors, G-Protein-Coupled</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.-</RegistryNumber><NameOfSubstance UI="D017853">Phosphotransferases (Alcohol Group Acceptor)</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.68</RegistryNumber><NameOfSubstance UI="C020077">1-phosphatidylinositol-4-phosphate 5-kinase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.1.-</RegistryNumber><NameOfSubstance UI="D019204">GTP-Binding Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004023" MajorTopicYN="N">Dictyostelium</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019204" MajorTopicYN="N">GTP-Binding Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008954" MajorTopicYN="N">Models, Biological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017853" MajorTopicYN="N">Phosphotransferases (Alcohol Group Acceptor)</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010838" MajorTopicYN="N">Phytophthora</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D043562" MajorTopicYN="N">Receptors, G-Protein-Coupled</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016415" MajorTopicYN="N">Sequence Alignment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2005</Year><Month>12</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2006</Year><Month>06</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2006</Year><Month>07</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>8</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>10</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>8</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16876997</ArticleId><ArticleId IdType="pii">S0966-842X(06)00179-X</ArticleId><ArticleId IdType="doi">10.1016/j.tim.2006.07.006</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>District de Cologne</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Cologne</li></settlement></list><tree><noCountry><name sortKey="Govers, Francine" sort="Govers, Francine" uniqKey="Govers F" first="Francine" last="Govers">Francine Govers</name><name sortKey="Meijer, Harold J G" sort="Meijer, Harold J G" uniqKey="Meijer H" first="Harold J G" last="Meijer">Harold J G. Meijer</name><name sortKey="Noegel, Angelika A" sort="Noegel, Angelika A" uniqKey="Noegel A" first="Angelika A" last="Noegel">Angelika A. Noegel</name></noCountry><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Bakthavatsalam, Deenadayalan" sort="Bakthavatsalam, Deenadayalan" uniqKey="Bakthavatsalam D" first="Deenadayalan" last="Bakthavatsalam">Deenadayalan Bakthavatsalam</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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